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AGE/SEX RELATED REFERENCE RANGES
Index
Alpha-1 Antitrypsin
Caeruloplasmin
Corrected Calcium
Creatinine
Creatinine Clearance (Female)
Creatinine Clearance (Male)
Free T4 / TSH
Immunoglobulins
IGF-1
IgG Subclasses
IgE
Phosphate
PSA
Transferrin Saturation
Urea
CREATININE
| Age |
Male |
Female |
| *Up to 1 year |
20 – 66 |
20 – 66 |
| *1 to 3 years |
24 – 70 |
24 – 70 |
| *4 to 7 years |
35 – 75 |
35 – 75 |
| *8 to 14 years |
44 – 90 |
44 – 90 |
| *14 to 17 years |
60 – 110 |
55 – 95 |
| 18 to 27 years |
78 –
145 |
60 –
115 |
| 28 to 40 years |
78 –
135 |
60 –
107 |
| 41 to 54 years |
78 –
128 |
60 –
101 |
| 55 to 66 years |
78 –
122 |
60 –
97 |
| 67 to 78 years |
78 –
118 |
60 –
95 |
| 79 to 87 years |
78 –
115 |
60 –
93 |
| Over 87 years |
78 –
113 |
60 –
91 |
- *Savory DJ. Reference ranges for serum creatinine in infants,
children and adolescents. Ann Clin Chem 1990; 27: 99-101
- Calculated from MDRD eGFR formula adjusted for
local creatinine results (June 2006)
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UREA
| Age |
Male |
Female |
| *0 to 13 years |
1.7 – 6.7 |
1.7 – 6.7 |
| 13 to 44 years |
3.2 – 7.5 |
2.7 – 6.7 |
| 45 to 54 years |
3.4 – 8.2 |
2.9 – 7.4 |
| 55 to 64 years |
3.4 – 8.2 |
3.4 – 8.0 |
| 65 to 67 years |
3.4 – 9.6 |
3.4 – 8.0 |
| 68 to 71 years |
3.6 – 10.2 |
3.4 – 9.0 |
| Over 71 years |
3.7 – 12.1 |
3.2 – 10.0 |
- *Green A, Isherwood D. Reference Data excluding Neonates. In: Clayton
BE, Round JM, ed. Clinical Biochemistry and the Sick Child. Oxford: Blackwell
Scientific Publications, 1994: 540.
- Whitehead TP, Robinson D, Hale AC, Bailey AR. Clinical Chemistry
and Haematology : Adult Reference Values. London: BUPA Medical Research and
Development Ltd, 1994: 24-25.
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CORRECTED CALCIUM
| Age |
Male
/ Female |
| 0 to 1 month |
2.25 – 2.78 |
| 1 to 3 months |
2.25 – 2.75 |
| 3 to 6 months |
2.25 – 2.72 |
| 6 to 12 months |
2.25 – 2.68 |
| 1 to 2 years |
2.20 – 2.65 |
| 2 to 3 years |
2.20 – 2.62 |
| 3 to 5 years |
2.20 – 2.60 |
| 5 to 9 years |
2.20 – 2.58 |
| 9 to 50 years |
2.20 – 2.55 |
| Over 50 years - Male |
2.20 - 2.60 |
| Over 50 years - Female |
2.20 -
2.64 |
1. Paediatric Chemical Pathology. Clayton BE, Jenkins,
Round JM. 1980
2. Adult reference range: In-house data on 2,007 GP/OP with normal ALP, renal
function and albumin (March 2001)
top
PHOSPHATE
| Age |
Male
/ Female |
| 0 to 1 month |
1.80 – 3.20 |
| 1 to 12 months |
1.40 – 2.10 |
| 1 to 14 years |
1.20 – 1.70 |
| 14 to 18 years |
1.00 – 1.60 |
| Over 18 years |
0.80 – 1.45 |
1. Clinical Chemistry: metabolic and clinical
aspects. Marshall W.J, Bangert S.K. 1995
top
TSH
| Age |
Male
/ Female |
| *Up to 2 weeks |
0.4 – 20.0 |
| *2 weeks to 6 weeks |
0.4 – 10.0 |
| Over 6 weeks |
0.4 – 5.0 |
- *Fisher DA. Management of congenital hypothyroidism. J Clin
Endocrin Metab 1991; 72: 523-529
- Roche Elecsys method insert.
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Free T4
| Age |
Male
/ Female |
| *Up to 6 weeks |
12.0 – 30.0 |
| Over 6 weeks |
12.0 – 23.0 |
- *Fisher DA. Management of congenital hypothyroidism. J Clin
Endocrin Metab 1991; 72: 523-529
- Roche Elecsys method insert.
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TRANSFERRIN (SATURATION)
Transferrin 2.0 - 3.5 g/L
Transferrin Saturation 15 - 50 %
Levels above 50% are referred for haemochromatosis genetic
analysis (if sample available) or comment requesting sample for genetic analysis.
- Sherwood RA, Pippard MJ, Peters TJ. Iron homeostasis and the
assessment of iron status. Ann Clin Biochem 1998; 35: 693-708.
top
PROSTATIC SPECIFIC ANTIGEN
| Age |
Male |
| Up to 50 years |
0.1 – 2.5 |
| 50 - 59 years |
0.1 - 3.5 |
| 60 - 69 years |
0.1 - 4.5 |
| 70 - 79 years |
0.1 - 6.5 |
| Over 79 years |
0.1 - 7.5 |
- Handbook of Clinical Immunochemistry (SAS Protein Reference Units)
1999; 312
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CALCULATED CREATININE CLEARANCE
(MALE)
| Age |
Male |
| Less than 30 years |
75 - 154 |
| 30 to 35 years |
71 - 146 |
| 36 to 40 years |
68 - 139 |
| 41 to 45 years |
65 - 132 |
| 46 to 50 years |
60 - 125 |
| 51 to 55 years |
54 - 118 |
| 56 to 60 years |
47 - 109 |
| 61 to 65 years |
41 - 100 |
| 66 to 70 years |
36 - 87 |
| Over 70 years |
32 - 75 |
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CALCULATED CREATININE CLEARANCE
(FEMALE)
| Age |
Female |
| Less than 30 years |
60 - 146 |
| 30 to 35 years |
56 - 133 |
| 36 to 40 years |
54 - 129 |
| 41 to 45 years |
52 - 126 |
| 46 to 50 years |
49 - 120 |
| 51 to 55 years |
45 - 114 |
| 56 to 60 years |
42 - 104 |
| 61 to 65 years |
38 - 94 |
| 66 to 70 years |
34 - 83 |
| Over 70 years |
30 - 72 |
- Nutrition and Health: an interuniversity study. Regional differences
in dietary habits, coronary risk factors and mortality rates in Belgium. Acta Cardiol
1984; 39: 285-92.
- Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum
creatinine. Nephron 1976; 16: 31-41.
top
ALPHA-1 ANTITRYPSIN
| Age |
Male
/ Female (g/L) |
| Birth |
0.9 – 2.2 |
| 6 months |
0.8 - 1.8 |
| 1 year |
1.1 - 2.0 |
| 5 years |
1.1 - 2.2 |
| 10 years |
1.4 - 2.3 |
| 15 years |
1.2 - 2.0 |
| Adult |
1.1 - 2.1 |
- Handbook of Clinical Immunochemistry (SAS Protein Reference Units)
1999; 304
top
IMMUNOGLOBULINS
| Age |
IgG
g/L |
IgA
g/L |
IgM
g/L |
| Up to 2 weeks |
5.0 - 17.0 |
0.01 - 0.15 |
0.02 - 0.20 |
| 2 to 6 weeks |
4.0 - 13.0 |
0.01 - 0.15 |
0.10 - 0.40 |
| 6 to 12 weeks |
2.1 - 7.7 |
0.05 - 0.40 |
0.10 - 1.00 |
| 3 - 6 months |
2.5 - 9.0 |
0.10 - 0.70 |
0.10 - 1.00 |
| 6 - 9 months |
2.5 - 9.0 |
0.10 - 0.70 |
0.40 - 1.60 |
| 9 - 12 months |
3.0 - 10.9 |
0.10 - 0.70 |
0.50 - 2.00 |
| 1 - 2 years |
3.1 - 13.8 |
0.30 - 1.30 |
0.50 - 2.00 |
| 2 - 3 years |
4.0 - 16.0 |
0.30 - 1.30 |
0.50 - 2.00 |
| 3 - 6 years |
4.0 - 16.0 |
0.40 - 2.00 |
0.50 - 2.00 |
| 6 - 9 years |
5.4 - 16.5 |
0.50 - 2.50 |
0.50 - 2.00 |
| 9 - 45 years |
5.4 - 16.5 |
0.70 - 3.00 |
0.50 - 2.00 |
| Over 45 years |
5.4 - 16.5 |
0.70 - 4.00 |
0.50 - 2.00 |
- Handbook of Clinical Immunochemistry (SAS Protein Reference Units)
1999; 310
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IMMUNOGLOBULIN
G SUBCLASSES
| Age |
IgG1
g/L |
IgG2
g/L |
IgG3
g/L |
IgG4
g/L |
| Up to 6 months |
1.5 - 3.0 |
0.3 - 0.5 |
0.1 - 0.6 |
0.01 - 0.10 |
| 6 to 24 months |
2.3 - 5.8 |
0.3 - 2.9 |
0.1 - 0.8 |
0.01 - 0.50 |
| 2 to 5 years |
2.3 - 6.4 |
0.7 - 4.5 |
0.1 - 1.1 |
0.01 - 0.80 |
| 5 to 10 years |
3.6 - 7.3 |
1.4 - 4.5 |
0.3 - 1.1 |
0.01 - 1.00 |
| 10 to 15 years |
3.8 - 7.7 |
1.3 - 4.6 |
0.2 - 1.2 |
0.01 - 1.10 |
| Over 15 years |
3.2 - 10.2 |
1.2 - 6.6 |
0.2 - 1.9 |
0.01 - 1.30 |
Handbook of Clinical Immunochemistry (SAS Protein
Reference Units) 1999; 310 top
IMMUNOGLOBULIN E
| Age |
Male
/ Female (kU/L) |
| Less than 1 month |
Less than 5 |
| 1 - 3 months |
Less than 11 |
| 3 -12 month |
Less than 29 |
| 1- 5 years |
Less than 52 |
| 5 - 10 years |
Less than 63 |
| 10 -15 years |
Less than 75 |
| Over 15 years |
Less than 81 |
- Handbook of Clinical Immunochemistry (SAS Protein Reference Units)
1999; 311
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CAERULOPLASMIN
| Age |
Male
/ Female (g/L) |
| Less than 4 months |
0.08 - 0.23 |
| 4 - 12 months |
0.12 - 0.35 |
| 1 - 10 years |
0.20 - 0.40 |
| 10 - 13 years |
0.15 - 0.23 |
| Adult |
0.20 - 0.60 |
- Handbook of Clinical Immunochemistry (SAS Protein Reference Units)
1999; 307
IGF-1
| Age |
Male/Female
(ng/ml) |
Median |
| Up to 3 years |
<40 - 100 |
|
| 4 to 6 years |
<40 - 175 |
|
| 7 to 9 years |
42 - 210 |
|
| 10 to 12 years |
50 - 280 |
|
| 13 to 15 years |
70 - 420 |
|
| 16 to 19 years |
60 - 420 |
|
| 20 - 29 years |
125 - 329 |
195 |
| 30 to 39 years |
120 - 330 |
189 |
| 40 to 49 years |
126 - 369 |
220 |
| 50 - 59 years |
108 - 263 |
166 |
| Over 59 years |
108 - 229 |
151 |
- Clinical Biochemistry, St. Bartholomew's Hospital, London
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