|
GUIDELINES
FOR ANTIEMETIC REGIME FOR CHEMOTHERAPY OUTPATIENTS
Emesis will vary with each patient and on the emetic
potential of the cytotoxic regime.
Anti emetic regime should be evaluated on each visit for
chemotherapy.
1st
Line
|
Drug
|
Dose
|
Route
|
Frequency
|
Side
effects and comments
|
|
Ondansetron
|
8mg
|
IV
|
when
giving chemotherapy
|
Constipation
Exchange
for Granisetron if not tolerated
|
|
Metoclopramide
|
10mg
|
PO
|
TDS
|
Extrapyramidal effects
|
2nd
Line
|
Drug
|
Dose
|
Route
|
Frequency
|
Side
effects and comments
|
|
Ondansetron
|
8mg
|
PO/IV
|
BD
|
Constipation
|
|
+/-
Metoclopramide
|
10mg
|
PO
|
TDS
|
Extrapyramidal
effects
|
3rd
Line – until
able to tolerate 2nd line oral anti emetics.
|
Drug
|
Dose
|
Route
|
Frequency
|
Side
effects and comments
|
|
Domperidone
|
30mg
|
PR
|
TDS
|
|
|