Synonyms |
|
Anti-neutrophil cytoplasmic
antibody
|
Clinical
Indications |
|
The
presence of any of the following features in the absence of
another obvious cause is an indication for ANCA testing:
-
Glomerulonephritis,
especially rapidly progressive GN
-
Pulmonary
hemorrhage, especially pulmonary-renal syndrome
-
Cutaneous
vasculitis, especially with systemic features
-
Multiple
lung modules
-
Chronic
destructive disease of the upper airway
-
Long-standing
sinusitis or otitis
-
Subglottic
tracheal stenosis
-
Mononeuritis
multiplex or peripheral neuropathy
-
Retro-orbital
mass
ANCA
repeats: after 2-3 months is reasonable to monitor therapy, or
to check for relapses if patient is in remission.
|
Test Includes |
|
Positive samples have a pattern
reported - C-ANCA is the cytoplasmic pattern associated with Wegener's, P-ANCA is the
perinuclear pattern associated with vasculitis disease. All positives have
MPO and
PR3 antibodies measured
|
Request Form |
|
Combined Pathology Blood form
(Yellow/Black)
|
Availability |
|
Analysed
by referral laboratory.
Urgent analysis must be discussed with Consultant Biochemist.
|
Turnaround
Time |
|
Two weeks
|
Specimen |
|
Serum
|
Volume |
|
2 ml
|
Container |
|
Yellow top (SST) tube
|
Lab. Handling |
|
Aliquot and store at 4°C
|
Causes
for
Rejection |
|
Assay within previous two months
|
Reference
Range |
|
Negative.
Conditions
associated with positive ANCA.
|