Synonyms

Anaphylactic drug reaction, plasma tryptase.

Clinical Indications

Intravenous 'drug' administration may cause immediate hypersensitivity (anaphylactic), or histamine release (anaphylactoid) reactions. These may range from minor (flushing, urticaria) to major (bronchospasm, cardiovascular collapse). They are due to the release of histamine and other vasoactive chemicals: they can be mimicked by other conditions - underlying pathology or pharmacological effects.

Test Includes

Plasma tryptase

Request Form

Combined Pathology Blood form (Yellow/Black). Full details should include complete patient ID; date & time of reaction; surgical procedure; all drugs administered; clinical signs and outcome; previous history; any risk factors; haematology results.
The National Adverse Anaesthetic Reaction Consultancy Service (NARCOS) may be contacted on 0114 243 4343. The Medicines Control Agency should also be informed.

Availability

Analysed by referral laboratory if specific criteria met.

Specific Criteria

Confirmation of anaphylactic drug reaction.

Turnaround Time

1 month

Specimen

Blood

Volume

2 ml

Container

Pink top (EDTA) blood tubes

Collection

Blood taken within 60 minutes, then 3 and 24 hours after reaction; duplicate samples should be collected for FBC.

Lab. Handling

Separate and store at -20°C, send all samples and documentation by post.