Synonyms |
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A4
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Clinical
Indications |
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Androstenedione
is not as useful as 17-OH progesterone in diagnosis of
congenital adrenal hyperplasia (CAH) due to 11ß- or
21-hydroxylase deficiency, but is helpful in management of
such patients. In CAH due to 17ß-hydroxysteroid dehydrogenase
deficiency male (46 XY) babies have female or ambiguous
genitalia and at puberty, marked virilization occurs. The
condition is characterised by increased androstenedione
relative to that of testosterone.
|
Request Form |
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Combined Pathology Blood form
(Yellow/Black)
|
Availability |
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Analysed by referral
laboratory if specific criteria met.
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Specific
Criteria |
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Management of CAH due to 11ß- or
21-hydroxylase deficiency. Diagnosis of 17ß-hydroxysteroid
dehydrogenase deficiency.
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Turnaround
Time |
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Two
weeks.
|
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Patient
Preparation |
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It is advisable to avoid stress.
For diagnosis of 17ß-hydroxysteroid dehydrogenase deficiency
in infants, stimulation with hCG may be required to achieve
serum androstenedione levels that can be measured for accurate
diagnosis.
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Specimen |
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Serum
|
Volume |
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1 ml
|
Container |
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Yellow top (SST) tube
|
Lab. Handling |
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Aliquot and
freeze at minus 20’C. Send
frozen in transport box to local referral laboratory. (AND & send;
NOAND & save).
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Causes for
Rejection |
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Not
meeting specific criteria for analysis. Unlabelled sample.
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Reference
Range |
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Adult:
Male 2.4 - 12.6 nmol/L, Female 1.0 - 12.2 nmol/L.
Prepubertal children: <3.5 nmol/L.
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