CONDITIONS ASSOCIATED WITH POSITIVE IF-ANA
TEST RESULTS
|
|
Freq. Positive ANA Result % |
|
Diseases for which ANA test very useful for diagnosis |
|
|
SLE |
95-100 |
|
Systemic sclerosis (scleroderma) |
60-80 |
|
Diseases for which ANA test sometimes useful for diagnosis |
|
|
Sjogren syndrome |
40-70 |
|
Idiopathic inflammatory myositis |
|
|
Diseases for which ANA tests useful for monitoring or prognosis |
|
|
Juvenile chronic oligoarticular arthritis with uveitis |
20-50 |
|
Raynaud phenomenon |
20-60 |
|
Conditions in which a positive ANA test is an intrinsic part of the diagnostic criteria |
|
|
Drug-induced SLE |
~100 |
|
Autoimmune hepatic disease |
~100 |
|
Mixed Connective Tissue Disease (MCTD) |
~100 |
|
Diseases for which ANA test is not useful for diagnosis |
|
|
Rheumatoid arthritis |
30-50 |
|
Multiple sclerosis |
25 |
|
Idiopathic thrombocytopenic purpura |
10-30 |
|
Thyroid disease |
30-50 |
|
Discoid lupus |
5-25 |
|
Infectious diseases |
variable |
|
Malignancies |
variable |
|
Patients with silicone breast implants |
15-25 |
|
Fibromyalgia |
15-25 |
|
Relatives of patients with autoimmune disease (e.g. SLE) |
5-25 |
|
Normal persons (prevalence of positive ANA increases with female sex and age) |
|
|
>1:40 (weak positive) |
20-30 |
|
>1:80 |
10-12 |
|
>1:160 |
5 |
|
>1:320 (strong positive) |
3 |
Kavanaugh A, Tomar R, Reveille J, Solomon D.H., Homburger H.A. Guidelines for clinical use of the Antinuclear Antibody Test and tests for specific autoantibodies to nuclear antigens. Presented at the College of American Pathologists Conference XXXII.