Synonyms

Extractable nuclear antibodies, Scl-70, Jo-1

Clinical Indications

Investigation and monitoring of connective tissue diseases.

Test Includes

• U1-RNP; RNP-Sm; Sm; Ro; La; Scl-70; Jo-1. U1-RNP is strongly associated with MCTD, and may be seen in SLE and RA
• RNP-Sm is seen in MCTD
• Sm is reasonably specific for SLE 
• Ro (SSA) is associated with Sjogren's, subacute cutaneous lupus and SLE
• La (SSB) is strongly associated with Sjogren's, and may be seen in SLE (often with Ro) 
• Scl-70 is seen in sclerosis/scleroderma 
• Jo-1 is seen in myositis and dermatomyositis.

Part of Profile

Automatically done on positive ANA samples

Request Form

Combined Pathology Blood form (Yellow/Black)

Availability

Analysed by referral laboratory.

Specific Criteria

Positive ANA, monitoring known positive ENA

Turnaround Time

Two weeks

Specimen

Serum

Volume

2 ml

Container

Yellow top (SST) tube

Lab. Handling

Aliquot and store at 4°C

Causes for Rejection

Assay within previous month

Reference Range

Negative