Clinical
Indications |
|
Investigation
and monitoring of B cell dyscrasias, especially light chain
only myeloma, MGUS, amyloid. Because of their shorter
half-life, FLC may show a quicker response to treatment then
intact immunoglobulin.
Further
investigation of an abnormal band in serum.
|
Request Form |
|
Combined Pathology Blood form
(Yellow/Black)
|
Availability |
|
Analysed if specific
criteria met
|
Specific
Criteria |
|
Request by Consultant
Haematologist or Biochemist
|
Turnaround
Time |
|
One week.
|
Specimen |
|
Serum
|
Volume |
|
2 ml
|
Container |
|
Yellow top (SST) tube
|
|
Collection |
|
No specific collection conditions.
|
|
Lab. Handling |
|
Store at 4°C
|
Causes for
Rejection |
|
Unlabelled
sample; assay within previous week.
|
Reference
Range |
|
Serum kappa FLC 3.3
– 19.4
mg/L
Serum lambda FLC 5.7
– 26.3
mg/L
Kappa/lambda ratio
0.26 – 1.65
Increased
levels may be seen with raised polyclonal immunoglobulin, and
in renal impairment. Abnormal
ratio indicates B cell dyscrasia
|