Synonyms |
|
Insulin-like
Growth Factor 1,
|
Clinical
Indications |
|
Screening
for acromegaly. An elevated IGF-1 in a patient with the
appropriate clinical picture is diagnostic. Occasionally
acromegalics may have a normal IGF-1 level at diagnosis so a growth
hormone suppression test remains the definitive diagnostic
test.
Follow up of treatment for acromegaly. IGF-1 should be
measured annually along with growth hormone. Elevated IGF-1
with normal growth hormone levels may indicate a need for
further lowering growth hormone levels.
|
|
Request Form |
|
Combined
Pathology Blood form (Yellow/Black)
|
Availability |
|
Analysed
by referral laboratory if specific criteria met.
|
Specific
Criteria |
|
Requested
by Consultant Endocrinologists or if agreed with Consultant
Biochemist.
|
Turnaround
Time |
|
2
weeks
|
Specimen |
|
Serum
|
Volume |
|
2
ml
|
Container |
|
Red
or pink top (plain) tube. Yellow top (SST) tubes should not be
used.
|
Collection |
|
Samples
must be transported to laboratory immediately. Patients must
attend Basildon phlebotomy for sample collection.
|
Lab.
Handling |
|
Separate
immediately into 2 aliquots and freeze at minus 20’C. Send
frozen in transport box to local referral laboratory..
|
Causes
for Rejection |
|
Not
meeting specific criteria for analysis. Delay in sample
reaching laboratory. Sample collected into tube containing
gel.
|
Reference
Range |
|
Age
Less than 4
years
4 to 7 years
7 to 10 years
10 to 13 years
13 to 16 years
17 to 18 years
19 to 20 years
21 to 30 years
31 to 40 years
41 to 50 years
51 to 60 years
61 to 70 years
Over 70 years
|
IGF-1 (ug/L)
49 - 289
50 - 297
57 - 388
88 - 693
183 - 996
163 - 731
127 - 483
117 - 329
109 - 284
94 - 252
81 - 255
69 - 200
55 - 188
|
|
|
|