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Test Directory -  Lead

Clinical Indications

Lead poisoning is a preventable condition that results from environmental exposure to lead. This exposure can result in permanent health damage, especially among children.In the UK the main sources of lead exposure are air-borne lead (from industrial sources and from the use of lead in petrol), water-borne lead (where lead dissolves readily from lead piping or from lead solder in water pipes, sometimes found in pre-1970s buildings), and occupational and hobby exposure (e.g. plumbers and stained glass artists).

Lead poisoning can affect almost all parts of the body, including the central nervous system, kidneys, and reproductive organs. It commonly causes weakness and abdominal discomfort and less often causes abdominal pain, vomiting, constipation, foot and wrist drop and anaemia. In children especially, it impairs cognitive development, which can lead to learning disabilities and behavioural problems. At very high levels, it can even result in hallucinations, coma, seizures, and death.

Screening: Adults who work in industries known for lead exposure, for example plumbers, lead miners, shipbuilders, construction workers, demolition workers and pottery manufacturers should be screened for lead exposure. Adults who have hobbies that involve lead-based paints, ceramics, soldering etc should also be tested.

Diagnosis: Symptoms, including fatigue, changes in mood, nausea, headache, tremors, weight loss, or decreased libido, may be due to lead poisoning. The test may also be useful in investigation of patients for peripheral neuropathy, anaemia, reproductive failure, encephalopathy, or memory loss, which are symptoms of lead poisoning.

Request Form

Combined Pathology Blood form (Yellow/Black)

Availability

Analysed by referral laboratory if specific criteria met.

Specific Criteria

Occupational Health screening of workers at risk from lead exposure (usually private or category 2 requests). Investigation of symptomatic patients.

Patient Preparation

No specific preparation required

Turnaround Time

2 weeks

Specimen

Whole blood (EDTA)

Volume

5-10 ml (paediatric 2-5 ml)

Container

Pink top (EDTA) tube

Lab. Handling

Store at 4C without separation. Send by first class post, early in week.

Causes for Rejection

Unlabelled sample. Not meeting specific criteria for analysis.

Reference Range

Occupational Monitoring:
If below 30 ug/dL monitor annually, 30 to 40 ug/dL monitor 6 monthly and above 40 ug/dL monitor 3 monthly. Action levels are 25 ug/dL (reproductive women), 40 ug/dL (young persons) and 50 ug/dL (others). 

Unit Conversion

To convert from umol/L to ug/dL multiply by 20.7

         

 


Last edited 07/08/08