Synonyms |
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Clinical
Indications |
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Any
disease which causes rapid destruction of striated muscle
(rhabdomyolysis) results in release of myoglobin into the
circulation. Myoglobin has a low molecular weight and is rapidly
filtered by the glomerulus. Urine
myoglobin is not contributory to rhabdomyolysis diagnosis or
prognosis and is not available.
However, if required, the
presence of myoglobin in urine may be detected using reagent
sticks. Both myoglobin and haemoglobin possess peroxidase
activity which gives positive results. It is not necessary to
further distinguish the cause of a positive reagent stick test
since there are other biochemical features which give strong
clues to the diagnosis.
|
Serum |
Myoglobinuria |
Haemoglobinuria |
|
Creatinine Kinase |
Very High |
Normal |
|
Visible haemolysis |
Absent |
Present |
|
Calcium |
Low |
Normal |
|
Urate |
Very High |
Normal |
|
Creatinine |
High |
Normal |
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Request
Form |
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Combined Pathology Blood form
(Yellow/Black or Blue for GP's)
|
Availability |
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On request.
|
Specific
Criteria |
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None
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Turnaround
Time |
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Same Day (Monday to Friday)
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Specimen |
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Urine
|
Volume |
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5 ml
|
Container |
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White
Capped Universal
|
Causes
for Rejection |
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Unlabelled sample
|
Interpretation |
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Serum
CK is the primary laboratory test used in investigation
of rhabdomyolysis.
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