Synonyms

S100B

Clinical Indications

S-100, an acidic calcium-binding protein, is present within cells of neuroendocrine origin. Recent studies suggest S-100 has particular utility in staging of malignant melanoma, in establishing prognosis, in evaluating treatment success and in predicting relapse. Circulating S-100 levels very sensitively detect metastatic growth of malignant melanoma, particularly in stage IV disease.

Request Form

Combined Pathology Blood form (Yellow/Black)

Availability

Analysed by referral laboratory if specific criteria met.

Specific Criteria

Assessment and monitoring of patients with malignant melanoma.

Turnaround Time

2 weeks

Specimen

Serum

Volume

2 ml

Container

Red or pink top (plain) tube. Yellow top (SST) tubes must not be used.

Lab. Handling

Aliquot and store at 4C. (S100 & send; TMND & save)

Causes for Rejection

Not meeting specific criteria for analysis.

Reference Range

Half-life in Serum

Tumour marker half-life calculator.

Interpretation

It has been shown that S-100 rises 3 months before clinical signs of recurrence. A S100 level of <0.2 is a reassuring negative result.